You still have to make changes to your Fallout 76 ini file to remove Depth of Field, but you might have to change more options with the launch version of the game. Updated Depth of Field removal instructions in Fallout 76 If an option is missing, you can try adding it yourself using the Fallout 4 config file as a guide – they’re pretty much the same. There may be some things you can change that aren’t accessible from the menu, and the file is pretty straightforward. While you’re there, you can inspect the other options as well. Hopefully this gets fixed soon, but until then, stick with making the ini file changes after you’ve tweaked the in-game settings to your desire. The game has been known to overwrite ini file changes when you do that. Keep in mind that you shouldn’t make any other changes in the game’s settings after you’ve done this, at least not from the menu itself. Save the file and run the game – everything should be in order now.

At the end of the section, add a line saying bDynamicDepthOfField=0. Open it up in notepad, and scroll down to the display section.

Fallout 4 turn off depth of field